As such, p21 acts as an effective inhibitor of S-phase DNA synthesis though permits NER, leading to the proposal that p21 acts to preferentially select polymerase processivity factors depending …

This article offers a comprehensive overview of 3 senescence phenotypes involving p21, elucidates the differences between p21 and p16, and examines the role of p21-dependent …

As a downstream target of p53, p21 is a powerful pan-inhibitor of CDK that plays a considerable role in cell cycle regulation, DNA repair, and cellular senescence [57,68,69].

Jul 20, 2025 · The p21 protein is a fundamental regulator of cell behavior. Encoded by the CDKN1A gene, p21 is a cyclin-dependent kinase inhibitor that governs the pace of cell …

Mar 6, 2017 · In normal cells, p21 maintains its genuine signature function as a cell cycle inhibitor and antiproliferative effector. p21 can mediate cellular senescence via p53-dependent and …

In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have …

Feb 3, 2020 · Cyclin-dependent kinase inhibitor 1, also known as CDK-interacting protein 1, or more simply as p21, is a cell cycle inhibitor that promotes both CDK/cyclin inhibition as well as …