MAP2 isoforms are neuron-specific cytoskeletal proteins enriched in dendrites and perikarya, implicating a role in determining and stabilizing neuronal morphology during neuron development.

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic marker. It …

Nov 14, 2025 · Complete information for MAP2 gene (Protein Coding), Microtubule Associated Protein 2, including: function, proteins, disorders, pathways, orthologs, and expression.

In vitro assays of microtubule dynamics have shown that MAP2 interacts with tubulin to promote microtubule assembly, and the expression of MAP2 isoforms is developmentally regulated, …

Jul 30, 2025 · MAP2 undergoes extensive phosphorylation, which dynamically modulates these interactions and alters MAP2 functions. This review provides a comprehensive overview of …

Jun 5, 2006 · They determined that the loss of microtubules was due to hypophosphorylation of Map2, which reduced the ability of Map2 to bind microtubules and promote tubulin …

Apr 13, 2025 · Gene target information for MAP2 - microtubule associated protein 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay …

May 31, 2023 · A superfamily of microtubule-associated proteins, MAP2, MAP4, and tau, promote the polymerization of microtubules, stabilize the formed microtubules, and affect the physical …

Type II MAPs (MAP2 and Tau) Type II MAPs are found exclusively in nerve cells in mammals. These are the most well studied MAPs— MAP2 and tau (MAPT)—which participate in …

Mar 13, 2025 · PDF | Microtubule-Associated Protein 2 (MAP2) is a critical structural protein in neurons, playing a key role in microtubule stabilization and neuronal... | Find, read and cite all …