Unlike freckles, these spots are not affected by sun exposure. They are often found on the face, neck, and upper part of the trunk but also on the palms, soles, and the sclerae (whites) of the eyes.

Lentigines — Reddish-brown to dark brown macules (surface skin lesion) generally occurring in a high number (10,000+) over a large portion of the skin, at times higher than 80% coverage. These can …

LEOPARD syndrome presents a wide array of symptoms, which can vary significantly among affected individuals. Some of the most common features include: Lentigines are small, dark spots on the skin, …

Multiple lentigines syndrome is a very rare inherited disorder that is noted by the black or dark brown spots on the skin, including the neck and head. Also called Leopard syndrome or Noonan syndrome, …

LEOPARD syndrome manifests diversely, with signs and severity varying among individuals. Skin abnormalities are common, with multiple lentigines appearing as small, flat, dark brown spots, …

Jan 10, 2018 · Centrofacial lentiginosis is an extremely rare inherited disorder characterized by the presence of multiple, small black or dark brown “freckle-like” spots (lentigines) appearing on the skin …

There are 3 types of LEOPARD syndrome, which are distinguished by their genetic cause. Type 1 is caused by mutations in the PTPN11 gene; type 2 is caused by mutations in the RAF1 gene; and type …

Individuals with LEOPARD syndrome 1 may develop numerous black or dark brown "freckle-like" spots on the skin. These spots are called lentigines. These spots can appear anywhere on the body, but …

The former name of NSML of LEOPARD stands for the different problems (signs and symptoms) of this disorder: L entigines -- large number of brown or black freckle-like skin markings that mainly affect …

LEOPARD is multiple congenital anomaly syndrome inherited in an autosomal dominant manner with full penetrance and variable expressivity. 1 Clinical diagnosis is based on multiple lentigines, typical …