The Advantages and Challenges of Using Endolysins in a Clinical …
Endolysins are bacteriophage-encoded peptidoglycan hydrolases that act to lyse bacterial cells by targeting their cell’s wall, particularly in Gram-positive bacteria due to their naturally exposed …
What Is an Endolysin and How Does It Work? - Biology Insights
Jun 22, 2025 · An endolysin is an enzyme that accelerates specific chemical reactions. Its role is to target and break down the rigid cell walls of bacteria. This action compromises their …
Lysin - Wikipedia
Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by host bacteria when infected with bacteriophages in order to cleave the cell wall during the final …
Endolysin - an overview | ScienceDirect Topics
Endolysins are bacteriophage-encoded enzymes that can specifically degrade the peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development of novel …
Frontiers | Endolysins: a new antimicrobial agent against …
May 20, 2024 · Endolysins, which are peptidoglycan hydrolases encoded by a bacteriophage, are a promising new family of antimicrobials. Endolysins have been demonstrated as an effective …
Designing the Next Generation of Endolysins: A Triple Strategy ...
6 days ago · Challenges inherent to each stage are critically analyzed, and future directions for endolysin development are discussed. Such multiple strategies provide a comprehensive …
The Unique Capability of Endolysin to Tackle Antibiotic ... - MDPI
Jan 25, 2025 · Endolysins, which are peptidoglycan hydrolases encoded by bacteriophages, represent a promising new class of antimicrobials.
Engineering strategies and challenges of endolysin as an …
Apr 9, 2024 · The review is to present the most recent progress on endolysin targeting Gram-negative bacteria and summarize the possible hindrance factors and the potential strategies …
Structural and functional analysis reveals the catalytic mechanism …
Jan 14, 2025 · Here, we analyzed the diversity of Streptococcus endolysins and identified a new endolysin, Ply2741, that exhibited broad-spectrum bactericidal activity. Our results …
Outlooks of endolysins with innolysins therapeutic potentials …
Jul 16, 2025 · Endolysins, bacteriophage-encoded enzymes that lyse bacterial cell walls, offer a promising avenue to traditional antimicrobials. These enzymes target specific peptidoglycan …