Figure 1: Overall structure of the GCGR–NNC0640–mAb1 complex. Figure 2: Ligand-binding mode of GCGR to NNC0640. Figure 3: Stalk and ECL1 in the full-length GCGR structure. The importance of the ...

Members of a new class of antivirals are being tested in U.S. clinical trials, and one has gained approval in Japan, but how ...

Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, ...

Lipid kinases are among the promising targets of new classes of drugs, due mainly to class I PI3Kα, which plays a crucial role in carcinogenesis and metastasis. This enzyme is hyperactive in 30-40% of ...

How can CU Professors/Administration keep students motivated to engage with the material at a level needed to be awarded credit for a college level course while still offering the flexibility and ...

Ford Motor Company has a dual-class stock structure of Class A and Class B shares. The roughly three billion Class A shares are for the general public like you and me, while the roughly 71 million ...