How a retrovirus, like HIV, reproduces and assembles new viruses is different than previously thought, according to Penn State College of Medicine researchers. Understanding the steps a virus takes ...

A team of scientists led by University of Georgia researchers has discovered a naturally occurring mechanism that blocks a critical step late in retrovirus replication. In the long term, the results ...

The re-transcribed DNA is then integrated into the genome of the host cell (Figure 2). This process requires the absence of the nuclear membrane and thus is restricted to the M-phase of proliferating ...

The increased frequency of drug resistance in isolates of the AIDS virus, HIV, makes identification of new antiviral targets an urgent necessity. Host genes required to support the replication of HIV ...

Understanding every step in the life cycle of a virus is crucial for identifying potential targets for treatment. Now, scientists were able to show how a virus from the retrovirus family - the same ...

Primates have evolved a variety of restriction factors that prevent retroviral replication. One such factor, TRIM5α, mediates a postentry restriction in many Old World primates. Among New World ...

Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths globally. Despite improvements in diagnostic and therapeutic approaches, the 5-year survival rate of this cancer is ...

It was early 1983 and Françoise Barré-Sinoussi of the prestigious Pasteur Institute in Paris was busy at the centrifuge trying to detect the presence of a retrovirus. The sample in the centrifuge came ...

Many animals, including humans, have DNA left over from ancient viral infections. In koalas, researchers are studying the process in real time. By James Gorman Koalas have been running into hard times ...

Bats have long been known as important hosts of zoonotic viral pathogens. Zoonotic viruses that bats transmit are capable of infecting humans and have caused devastating infections throughout the ...