Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation. Now, researchers from Kyushu University have demonstrated ...

Most cells rely on structural tethers to position chromosomes in preparation for cell division. Not so oocytes. Instead, a powerful intracellular stream pushes chromosomes far-off the center in ...

Figure 1: A light micrograph of a large oocyte in an ovary. RIKEN researchers have found that MPS1 promotes timely spindle bipolarization when oocytes in mice undergo ...

The growth and the onset of meiotic maturation of the mammalian oocyte are controlled by bidirectional interactions between the oocyte and the surrounding somatic cells. Junctional complexes and ...

KANSAS CITY, MO -- Most cells rely on structural tethers to position chromosomes in preparation for cell division. Not so oocytes. Instead, a powerful intracellular stream pushes chromosomes far-off ...

Increased meiotic spindle abnormalities and aneuploidy in oocytes of women of advanced maternal ages lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Despite the ...

Human eggs often contain the wrong number of chromosomes, leading to miscarriages and infertility. A research team has discovered that human eggs are missing an important protein, which acts as a ...

A protein known as MPS1 helps to ensure that a key process during cell division of oocytes—unfertilized egg cells—occurs in a timely manner, RIKEN biologists have discovered. This finding in mice may ...