Nature

Seven Novel Additional Small Mutations and a New Alternative Splicing in the Human Dystrophin Gene Detected by Heteroduplex Analysis and Restricted RT-PCR Heteroduplex Analysis ...

Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are X-linked recessive neuromuscular diseases which are caused by mutations in the gene coding for the 427-kD cytoskeletal protein ...
GEN

Rapid Screening for the Zygosity of CRISPR Mutations

The development of CRISPR/Cas9 revolutionized researchers’ ability to edit the genome at will. However, the nature of CRISPR edits is not entirely controllable or predictable. This uncertainty is due ...
Nature

Minimizing the secondary structure of DNA targets with a modified deoxynucleoside and its implication for nucleic acid analysis by hybridization

Some regions of nucleic acid targets are not accessible to heteroduplex formation with complementary oligonucleotide probes because they are involved in secondary structure through intramolecular ...