Cell transformation by the v-rel oncogene is mediated by the aberrant expression of genes that are normally tightly regulated by other Rel/NF-κB family members. Although a number of genes ...

Cory Abate (Rutgers University, Piscataway, N.J.): "The fos and jun oncogenes were isolated independently as cellular transforming genes. However, their protein products function cooperatively as ...

Many eukaryotic transcription factors form heterodimers between subunits with related DNA binding domains. The opposite sides of such heterodimeric complexes are likely to differ in their abilities to ...