ESPN NFL analyst Jeff Saturday explained why he picks the San Francisco 49ers to earn the NFC'S No. 1 seed with two weeks left in the regular season.

The San Francisco 49ers responded to clinching a playoff spot with a 48–27 victory over the Indianapolis Colts. The performance was the most complete showing fr

NBC Sports Bay Area asked 49ers fans which NFC team would be an ideal first-round NFL playoff matchup for San Francisco.

San Francisco 49ers star tight end George Kittle suffered an ankle injury in Monday night's 48-27 win over the Indianapolis Colts, and he feels that an illegal hip-drop tackle technique was to blame.

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game. The 49ers quarterback powered San Francisco to a 48-27 road victory with a career-high five passing touchdowns.

The San Francisco 49ers may have to navigate a couple of games without one of their superstars, but he avoided a longer-term injury vs. the Colts.

Skyy Moore didn't make it to the main Pro Bowl roster, but he was selected as an alternate. The strong stretch of performances in the last five games has got him there. Moore is yet another solid addition the 49ers made, and one that will aid them come playoff time.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

It's one thing to respect your elders, but the 49ers' young defensive players were taking it a little too far early on Monday night.

The San Francisco 49ers had a little fun on social media after their epic 48-27 win over the Indianapolis Colts on Monday Night Football.

The San Francisco 49ers beat the Indianapolis Colts on Monday. How did their performance affect their standing heading into Week 17?